Furthermore, the severity of VCIND differentially predicts survival such that moderate VCIND patients are 3–4 times more likely to die than mild VCIND patients and those without cognitive impairment within the follow-up period of 5 years. The prognosis of VCI is poor, with higher mortality rate and poorer functional outcome as compared to patients without cognitive impairment. Both VCIND and VaD are considered part of the spectrum of vascular cognitive impairment (VCI). Vascular cognitive impairment with no dementia (VCIND) is even more prevalent in post-stroke patients, with a reported rate of 47.7%. Post-stroke dementia includes vascular dementia (VaD) among others. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Ĭognitive deficits are common after stroke with 10% of patients developing dementia after their first-ever stroke and more than 30% had dementia after recurrent stroke. Dong was a recipient of the NUHS National Clinician Scientist Program award during this study. He can be contacted at the Memory Ageing and Cognition Center, Department of Pharmacology, Yoo Loo Lin School of Medicine, National University Health System, Singapore.įunding: This study is funded by a Center Grant (NMRC/CG/NUHS/2010) from the National Medical Research Council ( ). Christopher Li-Hsian Chen (email: who is acknowledged as a co-author in this study. Interested researchers may request access to the data in writing to Dr. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Because participants did not consent to have the data released publicly, the data underlying this study are available upon request. Received: JAccepted: FebruPublished: March 27, 2017Ĭopyright: © 2017 Tan et al. PLoS ONE 12(3):Įditor: Masaki Mogi, Ehime University Graduate School of Medicine, JAPAN (2017) Decline in changing Montreal Cognitive Assessment (MoCA) scores is associated with post-stroke cognitive decline determined by a formal neuropsychological evaluation. Citation: Tan HH, Xu J, Teoh HL, Chan BP-L, Seet RCS, Venketasubramanian N, et al.

Moca score 14